The drug-discovery projects will exploit established as well as innovative hit-identification strategies. Structure- and fragment-based design, classical structure-activity relationship (SAR) study, dynamic combinatorial chemistry and kinetic target-guided synthesis will be used to identify novel, selective and potent inhibitors of the MEP pathway enzymes. The binding mode of the most promising hits will be determined by … Continue reading WP 2: DESIGN AND SYNTHESIS OF INHIBITORS OF THE MEP PATHWAY